Nausea, extreme pain and fatigue, the symptoms normally associated with cancer, are not always symptoms of cancers themselves. Oftentimes extreme discomfort associated with many cancers is due to conventional treatments such as chemotherapy and surgery, none of which guarantee complete removal of the cancer.
As part of the Gemstone Honors Program, Team BASIC (Beating Acidic Surroundings Involving Cancer) is focused on improving developing treatments with the potential to permanently eradicate metastasized cancer with fewer side effects. Specifically, we are studying the effects of manipulating the acidity of the tumor’s surrounding environment (measured by extracellular pH) on the efficacy of cancer immunotherapy, a treatment that uses the body’s own immune system to help fight cancer.
Our initial data from preliminary experiments has been promising. It suggests that increasing alkalinity may damage cancer cells and enhance the killing ability of immune cells. This indicates that manipulating the pH of the environment surrounding tumors could improve the success of immunotherapy treatments.
For more information, watch this video or visit our website.
We Need YOUR Help:
We are seeking funding for our remaining in vitro studies, experiments done to form the scientific justifications that allow for further study using mouse models. The funds would be used to purchase antibodies to test the killing ability of treated immune cells, supplies for cell media and varying pH, and lab supplies such as pipette tips and cell plates. We can't do this without your help! We have the potential to make a meaningful contribution to fight against this terrible disease.
Team Members, Major(s); Minor(s):
Subul Beg, Biochemistry
Alice Chang, Economics and Finance; Survey Methodology
Ciara Egan, Biology - Cell Biology and Molecular Genetics
Lienna Feleke-Eshete, Government & Politics; French and Arabic
Allen Kao, Chemical Engineering
James Martinson, Bioengineering
Saadiya Sehareen, Biology
Benjamin Tunick, Bioengineering
Julia Wainger, Biology - Cell Biology and Molecular Genetics; Public Leadership
- Dr. Zhengguo Xiao (Mentor) - Associate Professor, Dept. Animal and Avian Sciences
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